Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 58, Issue -, Pages 34-40Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.04.011
Keywords
Zebrafish; Neonatal mouse; Heart regeneration
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Funding
- National Heart, Lung and Blood Institute [R01HL096121]
- Saban Research Institute
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Enhancing the endogenous regenerative capacity of the mammalian heart is a promising strategy that can lead to potential treatment of injured cardiac tissues. Studies on heart regeneration in zebrafish and neonatal mice have shown that cardiomyocyte proliferation is essential for replenishing myocardium. We will review recent advancements that have demonstrated the importance of Neuregulin 1/ErbB2 and innervation in regulating cardiomyocyte proliferation using both adult zebrafish and neonatal mouse heart regeneration models. Emerging findings suggest that different populations of macrophages and inflammation might contribute to regenerative versus fibrotic responses. Finally, we will discuss variation in the severity of the cardiac injury and size of the wound, which may explain the range of outcomes observed in different injury models. (C) 2016 Elsevier Ltd. All rights reserved.
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