Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 55, Issue -, Pages 99-110Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.03.012
Keywords
Planar polarity; Cell polarity; Cilia; Asymmetric cell division; Wing hairs; Stereocilia; Convergent extension; Hair follicles; Directional signaling; Planar cell polarity
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Funding
- NIH/NIAMS [R01AR066070]
- Searle Scholars Program
- Vallee Foundation Young Investigator Award
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The ability of cells to collectively orient and align their behaviors is essential in multicellular organisms for unidirectional cilia beating, collective cell movements, oriented cell divisions, and asymmetric cell fate specification. The planar cell polarity pathway coordinates a vast and diverse array of collective cell behaviors by intersecting with downstream pathways that regulate cytoskeletal dynamics and intercellular signaling. How the planar polarity pathway translates directional cues to produce polarized cell behaviors is the focus of this review. (C) 2016 Elsevier Ltd. All rights reserved.
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