4.6 Review

Energy sensing and cancer: LKB1 function and lessons learnt from Peutz-Jeghers syndrome

Journal

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 52, Issue -, Pages 21-29

Publisher

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.02.015

Keywords

Peutz-Jeghers syndrome; LKB1 kinase; Metabolism; Tumourigenesis

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We describe in this review increasing evidence that loss of LKB1 kinase in Peutz-Jeghers syndrome (PJS) derails the existing natural balance between cell survival and tumour growth suppression. LKB1 deletion can plunge cells into an energy/oxidative stress-induced crisis which leads to the activation of alternative and often carcinogenic pathways to maintain cellular energy levels. It therefore appears that although LKB1 deficiency can suppress oncogenic transformation in the short term, it can ultimately lead to more progressed and malignant phenotypes by driving abnormal cell differentiation, genomic instability and increased tumour heterogeneity. (C) 2016 Elsevier Ltd. All rights reserved.

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