Journal
SEMINARS IN CANCER BIOLOGY
Volume 40-41, Issue -, Pages 170-191Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2016.03.001
Keywords
Estrogen; Oxidative stress; Stem cells; Bioactive natural compounds; Breast cancer
Categories
Funding
- National Institutes of Health [R01AT007036, R01CA127645]
- National Institute of Environmental Health Sciences [ES005022]
- Charles and Johanna Busch Memorial Fund
- Trustees Research Fellowship Program at Rutgers, The State University of New Jersey
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Estrogen receptor (ER)-positive breast cancer, including luminal-A and-B, is the most common type of breast cancer. Extended exposure to estrogen is associated with an increased risk of breast cancer. Both ER-dependent and ER-independent mechanisms have been implicated in estrogen-mediated carcinogenesis. The ER-dependent pathway involves cell growth and proliferation triggered by the binding of estrogen to the ER. The ER-independent mechanisms depend on the metabolism of estrogen to generate genotoxic metabolites, free radicals and reactive oxygen species to induce breast cancer. A better understanding of the mechanisms that drive ER-positive breast cancer will help optimize targeted approaches to prevent or treat breast cancer. A growing emphasis is being placed on alternative medicine and dietary approaches toward the prevention and treatment of breast cancer. Many natural products and bioactive compounds found in foods have been shown to inhibit breast carcinogenesis via inhibition of estrogen induced oxidative stress as well as ER signaling. This review summarizes the role of bioactive natural products that are involved in the prevention and treatment of estrogen-related and ER-positive breast cancer. (C) 2016 Elsevier Ltd. All rights reserved.
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