Journal
SEMINARS IN ARTHRITIS AND RHEUMATISM
Volume 45, Issue 4, Pages 471-474Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semarthrit.2015.07.005
Keywords
Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA); Colchicine
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Objective: To evaluate the efficacy of colchicine in reducing the frequency of attacks in patients with PFAPA. Study design: We conducted a 6-month open label, randomized, controlled study among patients with PFAPA who attend the Pediatric Rheumatology Clinic at the Rambam Medical Center in Israel. A total of 18 patients aged 4-11 years (males:females ratio = 11:7) were randomized into a control group (I, 10 children) and a study group (II, 8 children). Group I was followed for 6 months without any intervention, and group II was initially followed for 3 months and was thereafter treated with colchicine for 3 additional months, according to standard regimen. During the 6-month period of the study the patients and their physician recorded all the episodes of PFAPA in a constructed log. DNA analyses for the 5 common FMF mutations in Israel were performed in 17 out of the 18 patients. Results: The number of episodes during the first 3 months was similar in both groups (group I 3.2 +/- 1.5, group II 4.9 +/- 2.3; p <= 0.12). Group II had significantly less PFAPA attacks in the second period while on colchicine therapy (4.9 +/- 2.3 vs. 1.6 +/- 1.2; p <= 0.01), in opposition to group I, where no difference in the number of attacks was noted between the first and second period of follow-up (3.2 +/- 1.5 vs. 2.7 +/- 1.5; p = 0.33). Of the 17 patients tested, 8 were carriers for FMF mutations (2 in group I and 6 in group II). Conclusion: Colchicine prophylaxis seems to be effective in reducing the number of attacks in PFAPA. (C) 2015 Elsevier Inc. All rights reserved.
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