Journal
CIRCULATION RESEARCH
Volume 116, Issue 6, Pages 925-936Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.116.304723
Keywords
blood pressure; epidemiology; hypertension; hypertension management
Funding
- National Institute of Health Research (NIHR) Oxford Biomedical Research Centre
- NIHR
- Rhodes Trust
- Oxford Martin School
- National Health and Medical Research Council of Australia
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Despite the vast amount of evidence on the benefits of blood pressure lowering accumulated to date, elevated blood pressure is still the leading risk factor for disease and disability worldwide. The purpose of this review is to summarize the epidemiological evidence underpinning the association between blood pressure and a range of conditions. This review focuses on the association between systolic and diastolic blood pressures and the risk of cardiovascular and renal disease. Evidence for and against the existence of a J-shaped curve association between blood pressure and cardiovascular risk, and differences in the predictive power of systolic, diastolic, and pulse pressure, are described. In addition, global and regional trends in blood pressure levels and management of hypertension are reviewed.
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