Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 8, Issue 337, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.aad7577
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Funding
- NIH (National Institute of Neurological Disorders and Stroke) [R01-NS080954]
- Stanford Bio-X Neuroventures program
- Bio-X Bioengineering Graduate Fellowship
- Bio-X and Stanford Interdisciplinary Graduate Fellowship
- Office of Technology Licensing Stanford Graduate Fellowship
- Howard Hughes Medical Institute International Student Research Fellowship
- Siebel Scholars Foundation
- Texas Instruments Stanford Graduate Fellowship
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Optogenetics offers promise for dissecting the complex neural circuits of the spinal cord and peripheral nervous system and has therapeutic potential for addressing unmet clinical needs. Much progress has been made to enable optogenetic control in normal and disease states, both in proof-of-concept and mechanistic studies in rodent models. In this Review, we discuss challenges in using optogenetics to study the mammalian spinal cord and peripheral nervous system, synthesize common features that unite the work done thus far, and describe a route forward for the successful application of optogenetics to translational research beyond the brain.
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