Journal
SCIENCE SIGNALING
Volume 9, Issue 422, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.aaf6029
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Funding
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council [1437702] Funding Source: researchfish
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Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors are the channels responsible for Ca2+ release from the endoplasmic and sarcoplasmic reticulum. Research in Science Signaling by Alzayady et al. show that all four IP3-binding sites within the tetrameric IP3R must bind IP3 before the channel can open, which has important consequences for the distribution of both IP3 and IP3R activity within cells.
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