Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 59, Issue 8, Pages 792-801Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-016-5088-4
Keywords
S100 Proteins; Zinc; Manganese; Copper
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Funding
- US National Institutes of Health [R01 AI101171, T32 ES007028]
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The S100 proteins are a unique class of EF-hand Ca2+ binding proteins distributed in a cell-specific, tissue-specific, and cell cycle-specific manner in humans and other vertebrates. These proteins are distinguished by their distinctive homodimeric structure, both intracellular and extracellular functions, and the ability to bind transition metals at the dimer interface. Here we summarize current knowledge of S100 protein binding of Zn2+, Cu2+ and Mn2+ ions, focusing on binding affinities, conformational changes that arise from metal binding, and the roles of transition metal binding in S100 protein function.
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