Journal
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
Volume 17, Issue 1, Pages 346-360Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14686996.2016.1189797
Keywords
Luminescent functionalized hybrid nanoparticles; biomechanical properties; surface-enhanced Raman spectroscopy (SERS); photothermal therapy (PTT); multi-modal imaging probe
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Funding
- National Science Foundation
- Utah Water Research Laboratory
- Utah Agriculture Experimental Station
- China Scholarship Council (CSC)
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1264498] Funding Source: National Science Foundation
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Highly dispersible Eu3+-doped CaMoO4@Au-nanorod hybrid nanoparticles (HNPs) exhibit optical properties, such as plasmon resonances in the near-infrared region at 790 nm and luminescence at 615 nm, offering multimodal capabilities: fluorescence imaging, surface-enhanced Raman spectroscopy (SERS) detection and photothermal therapy (PTT). HNPs were conjugated with a Raman reporter (4- mercaptobenzoic acid), showing a desired SERS signal (enhancement factor 5.0 x 10(5)). The HNPs have a heat conversion efficiency of 25.6%, and a hyperthermia temperature of 42 degrees C could be achieved by adjusting either concentration of HNPs, or laser power, or irradiation time. HNPs were modified with antibody specific to cancer biomarker epidermal growth factor receptor, then applied to human lung cancer (A549) and mouse hepatocyte cells (AML12), and in vitro PTT effect was studied. In addition, the biomechanical properties of A549 cells were quantified using atomic force microscopy. This study shows the potential applications of these HNPs in fluorescence imaging, SERS detection, and PTT with good photostability and biocompatibility. [GRAPHICS]
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