Journal
SCIENCE
Volume 351, Issue 6275, Pages 836-841Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aad8022
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Funding
- Defense Advanced Research Projects Agency (QuASAR program)
- NSF
- Center for Ultracold Atoms
- Army Research Office Multidisciplinary University Research Initiative
- National Security Science and Engineering Faculty Fellowship program,
- Gordon and Betty Moore Foundation
- Air Force Office of Scientific Research National Defense Science and Engineering Graduate Fellowship [32 CFR 168a]
- European Research Council
- German Academic Exchange Service (DAAD) P.R.I.M.E. Fellowship
- Herchel Smith-Harvard Undergraduate Summer Research Program
- Direct For Mathematical & Physical Scien
- Division Of Physics [1125846, 1506284] Funding Source: National Science Foundation
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Nuclear magnetic resonance spectroscopy is a powerful tool for the structural analysis of organic compounds and biomolecules but typically requires macroscopic sample quantities. We use a sensor, which consists of two quantum bits corresponding to an electronic spin and an ancillary nuclear spin, to demonstrate room temperaturemagnetic resonance detection and spectroscopy of multiple nuclear species within individual ubiquitin proteins attached to the diamond surface. Using quantum logic to improve readout fidelity and a surface-treatment technique to extend the spin coherence time of shallow nitrogen-vacancy centers, we demonstrate magnetic field sensitivity sufficient to detect individual proton spins within 1 second of integration. This gain in sensitivity enables high-confidence detection of individual proteins and allows us to observe spectral features that reveal information about their chemical composition.
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