Journal
SCIENCE
Volume 352, Issue 6287, Pages 816-818Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf6116
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Funding
- Brazilian Development Bank
- Funding Authority for Studies and Projects
- National Council of Scientific and Technological Development
- Foundation for Research Support in the State of Rio de Janeiro
- Sao Paulo Research Foundation [2014/21035-0]
- Coordination for the Improvement of Higher Education Personnel
- MRC [MC_PC_15102] Funding Source: UKRI
- Medical Research Council [MC_PC_15102] Funding Source: researchfish
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Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased considerably in Brazil; however, causality between the viral epidemic and malformations in fetal brains needs further confirmation. We examined the effects of ZIKV infection in human neural stem cells growing as neurospheres and brain organoids. Using immunocytochemistry and electron microscopy, we showed that ZIKV targets human brain cells, reducing their viability and growth as neurospheres and brain organoids. These results suggest that ZIKV abrogates neurogenesis during human brain development.
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