Journal
SCIENCE
Volume 351, Issue 6275, Pages 832-836Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aae0427
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Funding
- Max-Planck-Society
- Max-Planck-Institut fur Kohlenforschung
- China Scholarship Council
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Nitriles and alkenes are important synthetic intermediates with complementary reactivity that play a central role in the preparation of materials, pharmaceuticals, cosmetics, and agrochemicals. Here, we report a nickel-catalyzed transfer hydrocyanation reaction between a wide range (60 examples) of alkyl nitriles and alkenes. This strategy not only overcomes the toxicity challenge posed by the use of HCN in traditional approaches, but also encompasses distinct chemical advances, including retro-hydrocyanation and anti-Markovnikov regioselectivity. In a broader context, this work highlights an approach to the reversible hydrofunctionalization of alkenes through thermodynamically controlled transfer reactions to circumvent the use of volatile and hazardous reagents in the laboratory.
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