Journal
SCIENCE
Volume 352, Issue 6292, Pages 1408-1412Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aad8711
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Funding
- NCI NIH HHS [R21 CA187236, CA187236] Funding Source: Medline
- NIGMS NIH HHS [GM101316, T32 GM087237, T32GM007287, T32 GM007287, R01 GM101316] Funding Source: Medline
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RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N-6-methyladenosine (m(6)A), 5-methylcytosine (m(5)C), and pseudouridine (psi). Here we discuss the rapidly evolving understanding of the location, regulation, and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNA target sites are selected and how their modification is regulated. Diverse molecular consequences of individual m(6)A modifications are beginning to be revealed, but the effects of m(5)C and psi remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators.
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