Journal
SCIENCE
Volume 351, Issue 6276, Pages 976-981Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aad3997
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Funding
- Washington University McDonnell Center for Cellular and Molecular Neurobiology
- NIH [R01 NS068409, R01 DP1 DA035081, NIMH 2 R01 MH067122-11]
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In Drosophila, molecular clocks control circadian rhythmic behavior through a network of similar to 150 pacemaker neurons. To explain how the network's neuronal properties encode time, we performed brainwide calcium imaging of groups of pacemaker neurons in vivo for 24 hours. Pacemakers exhibited daily rhythmic changes in intracellular Ca2+ that were entrained by environmental cues and timed by molecular clocks. However, these rhythms were not synchronous, as each group exhibited its own phase of activation. Ca2+ rhythms displayed by pacemaker groups that were associated with the morning or evening locomotor activities occurred similar to 4 hours before their respective behaviors. Loss of the receptor for the neuropeptide PDF promoted synchrony of Ca2+ waves. Thus, neuropeptide modulation is required to sequentially time outputs from a network of synchronous molecular pacemakers.
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