Journal
SCIENCE
Volume 351, Issue 6280, Pages 1443-1446Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aad8361
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Funding
- Swiss National Science Foundation [PP00P3_123447]
- Synapsis Foundation
- Brain and Behavior Foundation (NARSAD Grant)
- Swiss SystemsX Interdisciplinary PhD Grant [51PHI0-141994]
- iGe3 PhD Award
- Swiss National Science Foundation
- National Center of Competence in Research (NCCR) Synapsy
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During corticogenesis, excitatory neurons are born from progenitors located in the ventricular zone (VZ), from where they migrate to assemble into circuits. How neuronal identity is dynamically specified upon progenitor division is unknown. Here, we study this process using a high-temporal-resolution technology allowing fluorescent tagging of isochronic cohorts of newborn VZ cells. By combining this in vivo approach with single-cell transcriptomics in mice, we identify and functionally characterize neuron-specific primordial transcriptional programs as they dynamically unfold. Our results reveal early transcriptional waves that instruct the sequence and pace of neuronal differentiation events, guiding newborn neurons toward their final fate, and contribute to a road map for the reverse engineering of specific classes of cortical neurons from undifferentiated cells.
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