Journal
SCIENCE
Volume 354, Issue 6310, Pages 343-347Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf9030
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Funding
- NIH [GM56265, GM089778, GM112763]
- Rural Development Administration of Republic of Korea [PJ01104001]
- Biomass Engineering Program of RIKEN
- Special Postdoctoral Researcher Program of RIKEN
- National Natural Science Foundation of China [31500991, 31570674, 31422041, 31371411]
- Fujian 2011 Program [2015-75]
- Grants-in-Aid for Scientific Research [25113006] Funding Source: KAKEN
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Cryptochromes are blue-light receptors that regulate development and the circadian clock in plants and animals. We found that Arabidopsis cryptochrome 2 (CRY2) undergoes blue light-dependent homodimerization to become physiologically active. We identified BIC1 (blue-light inhibitor of cryptochromes 1) as an inhibitor of plant cryptochromes that binds to CRY2 to suppress the blue light-dependent dimerization, photobody formation, phosphorylation, degradation, and physiological activities of CRY2. We hypothesize that regulated dimerization governs homeostasis of the active cryptochromes in plants and other evolutionary lineages.
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