Journal
SCIENCE
Volume 352, Issue 6289, Pages 1105-1109Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf1018
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Funding
- Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA)
- Agence Nationale de la Recherche (ANR) [ANR-14-CE09-0007]
- CEA program ToxNuc-E
- HelioBiotec platform - European Regional Development Fund
- HelioBiotec platform - Region Provence Alpes Cote d'Azur
- HelioBiotec platform - French Ministry of Research
- HelioBiotec platform - Commissariat a l'Energie Atomique et aux Energies Alternatives
- Region PACA
- Laboratory for Molecular Infection Medicine Sweden
- Knut and Alice Wallenberg Foundation
- Swedish Research Council
- Kempe foundation
- Chinese Scholarship Council
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Metal acquisition is a vital microbial process in metal-scarce environments, such as inside a host. Using metabolomic exploration, targeted mutagenesis, and biochemical analysis, we discovered an operon in Staphylococcus aureus that encodes the different functions required for the biosynthesis and trafficking of a broad-spectrum metallophore related to plant nicotianamine (here called staphylopine). The biosynthesis of staphylopine reveals the association of three enzyme activities: a histidine racemase, an enzyme distantly related to nicotianamine synthase, and a staphylopine dehydrogenase belonging to the DUF2338 family. Staphylopine is involved in nickel, cobalt, zinc, copper, and iron acquisition, depending on the growth conditions. This biosynthetic pathway is conserved across other pathogens, thus underscoring the importance of this metal acquisition strategy in infection.
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