Journal
SCIENCE
Volume 352, Issue 6283, Pages 366-370Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aad9272
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Funding
- Maryland Stem Cell Research Fund (MSCRF) [113345]
- Armed Forces Institute for Regenerative Medicine
- U.S. Department of Defense [W81XWH-11-2-0022]
- Jules Stein Professorship from the Research to Prevent Blindness Foundation
- Hartwell Foundation
- Cancer Center Core grant [P30CA006973]
- National Institutes of Health [R01AI077610]
- Bloomberg-Kimmel Institute for Cancer Immunotherapy
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Immune-mediated tissue regeneration driven by a biomaterial scaffold is emerging as an innovative regenerative strategy to repair damaged tissues. We investigated how biomaterial scaffolds shape the immune microenvironment in traumatic muscle wounds to improve tissue regeneration. The scaffolds induced a pro-regenerative response, characterized by an mTOR/Rictor-dependent T helper 2 pathway that guides interleukin-4-dependent macrophage polarization, which is critical for functional muscle recovery. Manipulating the adaptive immune system using biomaterials engineering may support the development of therapies that promote both systemic and local pro-regenerative immune responses, ultimately stimulating tissue repair.
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