Journal
SCIENCE
Volume 353, Issue 6305, Pages 1237-1240Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf6638
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Funding
- U.K. Biotechnological and Biological Sciences Research Council Institute Strategic Programme grant Understanding and Exploiting Plant and Microbial Secondary Metabolism [BB/J004596/1]
- John Innes Foundation
- BBSRC [BB/L014130/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/L014130/1, BBS/E/J/00000166] Funding Source: researchfish
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The ability to express heterologous proteins in plants has led to the concept of using plants as bioreactors or biofactories for the production of pharmaceutical proteins. Although initial studies were promising, the pathway to commercialization and deployment in a clinical setting has proven to be a somewhat rocky road. This Review examines the technical developments that have led to the current increase in interest in the use of plants for the production of pharmaceutical proteins, particularly in the context of clinical trials.
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