Journal
SCIENCE
Volume 354, Issue 6316, Pages 1140-1144Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aag1420
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Funding
- NIH [EY014924, NS076460]
- Stanford NeuroVentures grant
- Medical Research Council (MRC) [MRK0137851]
- Wellcome Trust [093104]
- Biotechnology and Biological Sciences Research Council [BB/F021399/1] Funding Source: researchfish
- Medical Research Council [MR/K013785/1] Funding Source: researchfish
- BBSRC [BB/F021399/1] Funding Source: UKRI
- MRC [MR/K013785/1] Funding Source: UKRI
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Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior.
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