Journal
SCIENCE
Volume 351, Issue 6269, Pages 169-172Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaa8714
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Funding
- NIH [GM095784, GM080177]
- NSF [1137676, MCB-1330451]
- Samsung Scholarship
- Ellison Medical Foundation
- Direct For Biological Sciences
- Emerging Frontiers [1137676] Funding Source: National Science Foundation
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All cellular materials are partitioned between daughters at cell division, but by various mechanisms and with different accuracy. In the yeast Schizosaccharomyces pombe, the mitochondria are pushed to the cell poles by the spindle. We found that mitochondria spatially reequilibrate just before division, and that the mitochondrial volume and DNA-containing nucleoids instead segregate in proportion to the cytoplasm inherited by each daughter. However, nucleoid partitioning errors are suppressed by control at two levels: Mitochondrial volume is actively distributed throughout a cell, and nucleoids are spaced out in semiregular arrays within mitochondria. During the cell cycle, both mitochondria and nucleoids appear to be produced without feedback, creating a net control of fluctuations that is just accurate enough to avoid substantial growth defects.
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