Journal
SCHIZOPHRENIA RESEARCH
Volume 176, Issue 2-3, Pages 95-99Publisher
ELSEVIER
DOI: 10.1016/j.schres.2016.08.014
Keywords
Body mass; Cannabis; Genetics; Psychotic disorder; Schizophrenia
Categories
Funding
- Geestkracht program of the Dutch Health Research Council (ZON-MW) [10-000-1002]
- Academic Psychiatric Centre AMC
- Ingeest
- Arkin
- Dijk en Duin
- Rivierduinen
- Erasmus MC
- GGZ Noord Holland Noord
- University Medical Centre Utrecht
- Altrecht
- Symfora
- Meerkanten
- Riagg Amersfoort
- Delta
- University Medical Center Groningen
- Lentis
- GGZ Friesland
- GGZ Drenthe
- Dimence
- Mediant
- GGZ De Grote Rivieren
- Parnassia Bavo Groep
- Maastricht University Medical Center
- GGZ Eindhoven
- GGZ Midden-Brabant
- GGZ Oost-Brabant
- GGZ Noord-Midden Limburg
- Mondriaan Zorggroep
- Prins Clauscentrum Sittard
- RIAGG Roermond
- Universitair Centrum KU Leuven campus Kortenberg
- CAPRI University of Antwerp
- PC Ziekeren Sint-Truiden
- PZ Sancta Maria Sint-Truiden
- GGZ Overpelt
- OPZ Rekem
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Cannabis use has been associated with favorable outcomes on metabolic risk factors. The cause of this relation is still unknown. In this study we investigated whether this effect is mediated by the AKT1 gene, as activation of the related enzyme by cannabis may cause metabolic changes. Six Single Nucleotide Polymorphisms (SNPs) of the AKT1 gene (rs1130214, rs1130233, rs2494732, rs2498784, rs3730358, and rs3803300) of patients with psychotic disorders (n = 623) were related to Body Mass Index (BMI), levels of glycosylated hemoglobin (HBA(1c)) and total metabolic risk. Next, mediation analysis was performed with BMI as outcome, cannabis as predictor, and AKT1 as mediator. Cannabis use was inversely related to BMI but not with levels of HBA(1c) and totalmetabolic risk. Moreover, out of 6 AKT1 SNPs, rs2494732 was associated with cannabis use, but AKT1 did not mediate the effect of cannabis on BMI. In conclusion, cannabis use is likely to be associated with a lower BMI in patients with a psychotic disorder. Moreover, AKT1 risk alleles may increase the incidence of cannabis use in patients with a psychotic disorder, but AKT1 does not appear to mediate the effect of cannabis on BMI. (C) 2016 Elsevier B.V. All rights reserved.
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