4.1 Review

The Grandberg reaction in the synthesis of biologically active compounds

Journal

RUSSIAN CHEMICAL BULLETIN
Volume 65, Issue 7, Pages 1709-1715

Publisher

SPRINGER
DOI: 10.1007/s11172-016-1499-4

Keywords

arylhydrazines; halocarbonyl compounds; tryptamines; indoles

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The review is focused on the Grandberg synthesis, namely, the synthesis of tryptamines from arylhydrazines and gamma-halocarbonyl compounds, as an exceptionally useful and efficient methodology to access biologically active indole heterocycles.

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