Journal
RNA
Volume 22, Issue 2, Pages 169-174Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.054502.115
Keywords
N6-methyladenosine; epitranscriptome; review
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Funding
- Abramson Family Center
- David and Fela Shapell Family Foundation INCPM Fund for Preclinical Studies
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Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made in recent years. The discussed aspects are also very relevant for a wide range of additional modifications on mRNA collectively coined the epitranscriptome.
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