Journal
RNA BIOLOGY
Volume 14, Issue 9, Pages 1153-1165Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2016.1259783
Keywords
ADAR; adenosine deaminase active on RNA; antiviral; APOBEC; apolipoprotein B editing catalytic subunit; ADAT; adenosine deaminase active on tRNA; cancer; cytidine deaminase; DNA mutation; epigenetics; HIV; human immunodeficiency virus; host defense; lncRNA; long noncoding RNA; mRNA; miRNA; microRNA; retrovirus; RNA editing; RNA modification
Categories
Funding
- Public Health Services [GM110568, GM110038]
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Apolipoprotein B mRNA Editing Catalytic Polypeptide-like 1 or APOBEC1 was discovered in 1993 as the zinc-dependent cytidine deaminase responsible for the production of an in frame stop codon in apoB mRNA through modification of cytidine at nucleotide position 6666 to uridine. At the time of this discovery there was much speculation concerning the mechanism of base modification RNA editing which has been rekindled by the discovery of multiple C to U RNA editing events in the 30 UTRs of mRNAs and the finding that other members of the APOBEC family while able to bind RNA, have the biological function of being DNA mutating enzymes. Current research is addressing the mechanism for these nucleotide modification events that appear not to adhere to the mooring sequence-dependent model for APOBEC1 involving the assembly of a multi protein containing editosome. This review will summarize our current understanding of the structure and function of APOBEC proteins and examine how RNA binding to them may be a regulatory mechanism.
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