Journal
RHEUMATOLOGY
Volume 56, Issue 9, Pages 1452-1460Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kew374
Keywords
microbiome; bacteria; inflammatory arthritis; spondyloarthritis; rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; dysbiosis
Categories
Funding
- Versus Arthritis [21228] Funding Source: researchfish
- Arthritis Research UK [21228] Funding Source: Medline
- Versus Arthritis [21228] Funding Source: Medline
Ask authors/readers for more resources
The human body consists of millions of commensal bacteria (the microbiome), with the intestinal tract being the most prevalent site of colonization. This colonization process begins at birth, and despite numerous factors such as ageing, diet and drug use affecting the microbiome make-up, by adulthood the composition of the gut bacteria is relatively consistent across local populations. The recent advent of new scientific techniques has enabled us to explore how the microbiome affects health and, in particular, has shed light on the involvement of the microbiome in the pathogenesis of inflammatory disease. In this review we highlight the current evidence for microbiome manipulation in inflammatory arthritis in animal and human models and discuss potential therapeutics targeting the microbiome as treatment for these diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available