Journal
RHEUMATOLOGY
Volume 55, Issue 9, Pages 1548-1555Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kev420
Keywords
B cell activating factor (BAFF); BAFF receptor; Sjogren's syndrome
Categories
Funding
- Biomedical Research Council [BRC09/III]
- Arthritis Research UK [18106, 19607]
- Versus Arthritis [18106, 19607] Funding Source: researchfish
Ask authors/readers for more resources
SS is an autoimmune condition characterized by exocrine gland destruction, autoantibody production, immune complex deposition and systemic complications associated with lymphocytic infiltration of many organs. Genetic, environmental and viral factors play a role in disease aetiology, however, the exact mechanisms driving the immunopathogenesis of SS remain uncertain. Here we discuss a role for B cell activating factor (BAFF), whereby B cell hyperactivity and increased BAFF secretion observed in patients and animal models of the disease can be explained by the altered expression of cell-specific BAFF/BAFF receptor (BAFF-R) variants in several immune cell types. Understanding the role of BAFF/BAFF-R heterogeneity in SS pathogenesis could help to facilitate new treatment strategies for patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available