Journal
CHROMOSOMA
Volume 125, Issue 1, Pages 51-63Publisher
SPRINGER
DOI: 10.1007/s00412-015-0526-9
Keywords
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Funding
- Austrian Science Foundation (FWF) [P26882, P26845, SFB 43-13]
- German Research Foundation (DFG) [LI 2431 2-1]
- Austrian Science Fund (FWF) [W1207, P26882, P26845] Funding Source: Austrian Science Fund (FWF)
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Adenosine to inosine editing (A to I editing) is a cotranscriptional process that contributes to transcriptome complexity by deamination of adenosines to inosines. Initially, the impact of A to I editing has been described for coding targets in the nervous system. Here, A to I editing leads to recoding and changes of single amino acids since inosine is normally interpreted as guanosine by cellular machines. However, more recently, new roles for A to I editing have emerged: Editing was shown to influence splicing and is found massively in Alu elements. Moreover, A to I editing is required to modulate innate immunity. We summarize the multiple ways in which A to I editing generates transcriptome variability and highlight recent findings in the field.
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