Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 43, Issue 5, Pages 3121-3130Publisher
SPRINGER
DOI: 10.1007/s11164-016-2814-2
Keywords
Hantzsch reaction; Acridine-1,8-dione; Hexahydroquinoline; Potassium dihydrogen phosphate; Aqueous ethanol
Categories
Funding
- National Natural Science Foundation of China [21403100]
- National Natural Science Foundation of Liaoning Province
- Doctoral Scientific Research Foundation [20141100]
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A simple, clean, and economical methodology for the synthesis of acridine-1,8-dione and hexahydroquinoline derivatives via Hantzsch-type condensation has been described. This study highlights the development of a new green pathway for the preparation of substituted 1,4-dihydropyridines derivatives. The mild, cheap, and nontoxic potassium dihydrogen phosphate (KH2PO4) is proved to be an efficient catalyst for the above multi-component reaction to get excellent yields. Widely available and mostly benign catalyst, eco-friendly solvent, and easy purification are among the several attractive features.
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