A green route towards substituted 2-amino-4H-chromenes catalyzed by an organobase (TBD) functionalized mesoporous silica nanoparticle without heating

1,5,7-Triazabicyclo-[4,4,0]-dec-1-ene functionalized mesoporous silica nanoparticle promoted one-pot multicomponent synthesis of 2-amino-4H-chromenes from a phenolic component, different aldehydes and malononitrile was achieved in aqueous media at room temperature. The methodology promises advantages of short reaction times, environmentally benign conditions, high yields, and operational convenience. The catalyst was reused several times without significant loss in activity.

Automated summary

The functionalized mesoporous silica nanoparticle promoted synthesis of 2-amino-4H-chromenes from phenolic components, different aldehydes, and malononitrile in aqueous media at room temperature. The method offers advantages of short reaction times, environmentally friendly conditions, high yields, and operational convenience. The catalyst can be reused multiple times without significant loss in activity.