Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 42, Issue 7, Pages 6195-6208Publisher
SPRINGER
DOI: 10.1007/s11164-016-2454-6
Keywords
Guanidinyl benzothiazole; Antioxidant activity; DPPH assay; ABTS assay; Antimicrobial
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Funding
- Department of Science and Technology, Ministry of Science and Technology, New Delhi, India [IF130464]
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A series of N-phenyl-substituted and disubstituted guanidinyl benzothiazole derivatives 4a-4m were synthesized and characterized as novel antimicrobial and antioxidant agents. The in-vitro antioxidant activities of these compounds were evaluated and compared with commercial antioxidants, using ascorbic acid (AA) and employing 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay and 2,2'-azino-bis (3-ethylbenzthiazoline- 6-sulphonic acid (ABTS) assay. The results showed that IC50 values of compounds 4a and 4m were similar to the IC50 values of the standard. This assay indicates the good activities of these compounds. In addition, the in-vitro antimicrobial activities of these compounds were evaluated and the results demonstrated that the compounds 4i and 4l exhibited excellent antimicrobial activities. Compounds 4c and 4i having electron withdrawing groups at p-position and compound 4l and 4m having electron donating groups at o-position showed better antimicrobial activities compared to the standard.
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