Journal
RESEARCH IN VETERINARY SCIENCE
Volume 105, Issue -, Pages 41-46Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2016.01.005
Keywords
Inflammatory colorectal polyp; Inflammatory bowel disease; Miniature dachshund; Fecal microbiota; 16S rRNA sequencing; Next generation sequencer
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Funding
- Japan Society for the Promotion of Science (KAKENHI) [26292159, 15H06153]
- Grants-in-Aid for Scientific Research [15H06153, 26292159] Funding Source: KAKEN
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Chronic gastrointestinal disease is associated with the alteration of gastrointestinal microbiota. Inflammatory colorectal polyps (ICRPs) are commonly observed in miniature dachshunds (MDs) in Japan and are characterized by multiple polyps that are restricted in the colorectal mucosa with severe neutrophil infiltration. This study was aimed to compare the fecal microbiota of ICRP-affected MDs with that of healthy MDs. High-throughput sequencing of amplicons derived from the V3-V4 region of the 16S rRNA gene was applied using the Illumina MiSeq system. Principal coordinates analysis revealed that fecal microbiota of ICRP-affected MDs was significantly altered compared with that of healthy MDs. Proportions of Fusobacteriaceae, Helicobacteraceae, Porphyromonadaceae, and Turicibacteraceae were significantly more abundant in ICRP-affected MDs, while those of Lachnospiraceae were significantly less abundant in ICRP-affected MDs compared with healthy MDs. These results suggest that the dysbiosis is associated with ICRPs and is a potential therapeutic target, though further investigations are needed. (C) 2016 Published by Elsevier Ltd.
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