Journal
RESEARCH IN VETERINARY SCIENCE
Volume 105, Issue -, Pages 134-135Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2016.02.003
Keywords
Colistin resistance; mcr-1; PmrAB; Plasmid; S. enterica; E. coli
Categories
Funding
- Ministry of Innovation, Science and Technology of Spain [AGL2012-39028-C03-01, AGL2012-39028-C03-03]
- Department of Employ, Enterprise and Innovation of the Regional Government of Extremadura, Spain [CTS001]
- University of Extremadura (Group MIVET)
- Autonomous Community of Madrid, Spain [S2013/ABI-2747]
- FPI programme of the Spanish Ministry of Economy and Competitiveness [BES-2013-065003]
- Spanish Ministry of Agriculture, Food and Environment
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Recent findings suggest that use of colistin as a last resort antibiotic is seriously threatened by the rise of a new plasmid mediated mechanism of resistance (MCR-1). This work identifies, for the first time in Southern Europe, the gene mcr-1 in nine strains from farm animals (poultry and swine) corresponding to five Escherichia coli and four Salmonella enterica, among which three belong to serovar Typhimurium and one to Rissen. The MCR-1 was found encoded by a plasmid highly mobilizable by conjugation to the E. coil J53 strain. Two E. coil strains carried two determinants, mcr-1 plus pmrA or pmrB mutations, known to confer colistin resistance. (C) 2016 Elsevier Ltd. All rights reserved.
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