Journal
REPRODUCTIVE TOXICOLOGY
Volume 65, Issue -, Pages 123-132Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2016.07.004
Keywords
Di(2-ethylhexyl) phthalate (DEHP); Polychlorinated biphenyls (PCBs); Testis; Testosterone; Mouse; EDs mixture
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Funding
- EU [REEF GA 212885]
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We investigated the effects of maternal exposure to the plasticizer di(2-ethylhexyl) phthalate (DEHP) and the organic industrial compounds polychlorinated biphenyls (PCBs), singly and combined, on the reproductive function of male mouse offspring. Mice dams were exposed throughout pregnancy and lactation to 1 mu g PCBs (101 +118)/kg/day, 50 mu g DEHP/kg/day, or the DEHP/PCB mixture in the diet. The mixture induced permanent alterations in adult F1 males' reproductive health in a way, differently from the single compounds. Depending on the endpoint, we observed: (1) synergy in altering the gross and histological morphology of the testis; (2) antagonism on the expression levels of genes involved in pituitary-gonadal cross-talk; (3) non-interactions on sperm parameters and testosterone production. This study illustrates the complex action of a DEHP/PCB mixture, leading to a unique panel of effects on the male reproductive system, indicating the need for research on the reproductive hazards of combined endocrine disruptors. (C) 2016 Elsevier Inc. All rights reserved.
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