Journal
REPRODUCTIVE TOXICOLOGY
Volume 62, Issue -, Pages 71-76Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2016.04.028
Keywords
Disinfection by-products; Haloacetic acids; Ovary; Folliculogenesis; Steroidogenesis
Categories
Funding
- NIH [R01ES019178, R01 DK 093690, T32 ES 007326, T32 ES 007015]
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Water disinfection greatly reduced the incidence of waterborne diseases, but the reaction between disinfectants and natural organic matter in water leads to the formation of drinking water disinfection by-products (DBPs). DBPs have been shown to be toxic, but their effects on the ovary are not well defined. This study tested the hypothesis that monohalogenated DBPs (chloroacetic acid, CAA; bromoacetic acid, BAA; iodoacetic acid, IAA) inhibit antral follicle growth and steroidogenesis in mouse ovarian follicles. Antral follicles were isolated and cultured with either vehicle or DBPs (0.25-1.00 mM of CAA; 2-15,M of BAA or IAA) for 48 and 96 h. Follicle growth was measured every 24 h and the media were analyzed for estradiol levels at 96 h. Exposure to DBPs significantly inhibited antral follicle growth and reduced estradiol levels compared to controls. These data demonstrate that DBP exposure caused ovarian toxicity in vitro. (C) 2016 Elsevier Inc. All rights reserved.
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