Journal
REPRODUCTIVE TOXICOLOGY
Volume 63, Issue -, Pages 151-160Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2016.06.005
Keywords
Cadmium; Development; Gestation; Lactation; Testis; Zinc
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Funding
- Ministry of Higher Education, Scientific Research and Technology of Tunisia
- Natural Sciences and Engineering Research Council of Canada (NSERC) [04607-2014]
- University of Monastir, Tunisia
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To assess the effects of exposure to Cd and Zn on rat testicular development, offspring, from mothers receiving either tap water, Cd, Zn or Cd + Zn during gestation and lactation periods, were observed on gestational day (GD) 20 and on postnatal days (PND) 12, 21 and 35. During gestation, Cd induced maternal hypozincemia and less transfer of Zn to the fetus. During lactation, progressive Cd accumulation and Zn depletion in testis at PND12 and PND21 were noted. An increase of abnormal seminiferous tubules and a decrease in testis weight and plasmatic testosterone concentration were also observed at PND21 and PND35 respectively. Interestingly, Zn supply induced a significant protection against Cd toxicity. These results suggest that the toxic effects of Cd observed during development are mediated by the disruption of Zn metabolism, which is established in mothers during pregnancy causing Zn deficiency in fetuses and continues to become more pronounced during lactation. (C) 2016 Elsevier Inc. All rights reserved.
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