Journal
REPRODUCTIVE TOXICOLOGY
Volume 62, Issue -, Pages 77-86Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2016.04.021
Keywords
Marijuana; Smoking; BMI; Pregnancy outcome; Spontaneous preterm birth
Categories
Funding
- National Health and Medical Research Council (NHMRC) [GNT1020749]
- Science Foundation Ireland [12/RC/2272]
- Premier's Science and Research Fund
- South Australian Government
- NHMRC [GNT519225]
- Foundation for Research Science and Technology
- Health Research Council [04/198]
- Auckland District Health Board Charitable Trust
- Health Research Board of Ireland [CSA/2007/2]
- National Health Service NEAT Grant [FSD025]
- Biotechnology and Biological Sciences Research council [GT084]
- University of Manchester
- Guy's and St. Thomas' Charity (King's College London)
- Tommy's charity (King's College London)
- Tommy's charity (University of Manchester)
- Cerebra UK (University of Leeds)
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Widespread legalisation of marijuana raises safety concerns for its use in pregnancy. This study investigated the association of marijuana use prior to and during pregnancy with pregnancy outcomes in a prospective cohort of 5588 nulliparous women from the international SCOPE study. Women were assessed at 15 +/- 1 and 20 +/- 1 weeks' gestation. Cases [278 Preeclampsia, 470 gestational hypertension, 633 small-for-gestational-age, 236 spontaneous preterm births (SPTB), 143 gestational diabetes] were compared separately with 4114 non-cases. Although the numbers are small, continued maternal marijuana use at 20 weeks' gestation was associated with SPTB independent of cigarette smoking status [adj OR 2.28 (95% CI:1.45-3.59)] and socioeconomic index (SEI) [adj OR 2.17 (95% a1.41-3.34)]. When adjusted for maternal age, cigarette smoking, alcohol and SEI, continued maternal marijuana use at 20 weeks' gestation had a greater effect size [adj OR 5.44 (95% CI 2.44-12.11)]. Our data indicate that increasing use of marijuana among young women of reproductive age is a major public health concern. (C) 2016 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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