Journal
REPRODUCTIVE SCIENCES
Volume 24, Issue 5, Pages 646-655Publisher
SPRINGER HEIDELBERG
DOI: 10.1177/1933719116667606
Keywords
insulin resistance; pathogenesis; PI3K-Akt; polycystic ovary syndrome; signaling pathway
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Funding
- Guangdong Natural Science Foundation [S2013010011984]
- Science and Technology Planning Project of Guangdong Province [2014A020212237]
- Guangdong provincial population and Family Planning Commission [20133071]
- Guangzhou Municipal Science and Technology Innovation Council [201510010290]
- Traditional Chinese Medicine Bureau Of Guangdong Province [2010247]
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This review aimed to focus on the recent progress of the understanding of the role of phosphatidylinositol 3-kinase (PI3K) in polycystic ovary syndrome (PCOS). In recent years, it has been increasingly recognized that PI3K plays an important role in PCOS whose pathogenesis is unclear. However, research continues into revealing the details of how PI3Ks are involved in developing PCOS. Previous studies have shown that activation of the PI3K-protein kinase B (Akt) signaling pathway has important effects on insulin resistance and endometrial cancer. Knowledge of the action of PI3K in PCOS might provide valuable information to further validate the pathogenesis of PCOS and suggest new methods of treatment.
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