Journal
REGENERATIVE MEDICINE
Volume 11, Issue 6, Pages 571-587Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2016-0042
Keywords
3D printing; additive manufacturing; biomaterials; bioreactor; bone tissue engineering; cell-based therapy
Categories
Funding
- NIH [R01-DE013740, R01-AR061460]
- Army, Navy, NIH, Air Force, VA, and Health Affairs [W81XWH-14-2-0004]
- US Army Medical Research Acquisition Activity [W81XWH-14-2-0004]
- 3DBioResins (Pepper Pike, OH, USA)
- 3DServicePros, LLC (Pepper Pike, OH, USA)
- Osteoplastics, LLC
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Bone tissue engineering (BTE) intends to restore structural support for movement and mineral homeostasis, and assist in hematopoiesis and the protective functions of bone in traumatic, degenerative, cancer, or congenital malformation. While much effort has been put into BTE, very little of this research has been translated to the clinic. In this review, we discuss current regenerative medicine and restorative strategies that utilize tissue engineering approaches to address bone defects within a clinical setting. These approaches involve the primary components of tissue engineering: cells, growth factors and biomaterials discussed briefly in light of their clinical relevance. This review also presents upcoming advanced approaches for BTE applications and suggests a probable workpath for translation from the laboratory to the clinic.
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