Journal
REGENERATIVE MEDICINE
Volume 11, Issue 8, Pages 871-881Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2016-0125
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Funding
- Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences [NIH R01AR063698, NIH DP1 AR068147]
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Regenerative engineering has been defined as the convergence of Advanced Materials Sciences, Stem Cell Sciences, Physics, Developmental Biology and Clinical Translation for the regeneration of complex tissues and organ systems. Anterior cruciate ligament (ACL) reconstruction necessitates the regeneration of bone, ligament and their interface to achieve superior clinical results. In the past, the ACL has been repaired with the use of autologous and allogeneic grafts, which have their respective drawbacks. Currently, investigations on the use of biodegradable matrices to achieve knee stability and permit tissue regeneration are making promising advancements. In the future, utilizing regenerative biology cues to induce an endogenous regenerative response may aid the enhancement of clinical ACL reconstruction outcomes.
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