4.2 Article

THE INTERNATIONAL NUCLEAR WORKERS STUDY (INWORKS): A COLLABORATIVE EPIDEMIOLOGICAL STUDY TO IMPROVE KNOWLEDGE ABOUT HEALTH EFFECTS OF PROTRACTED LOW-DOSE EXPOSURE

Journal

RADIATION PROTECTION DOSIMETRY
Volume 173, Issue 1-3, Pages 21-25

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/rpd/ncw314

Keywords

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Funding

  1. US Centers for Disease Control and Prevention [5RO3 OH010056-02]
  2. Ministry of Health, Labour and Welfare of Japan [2012-02-21-01]
  3. AREVA
  4. EDF
  5. National Institute for Occupational Safety and Health
  6. US Department of Energy
  7. US Department of Health and Human Services
  8. University of North Carolina from National Institute for Occupational Safety and Health [R03 OH-010056]

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INWORKS is a multinational cohort study, gathering 308 297 workers in the nuclear industry in France, the United Kingdom and the United States of America, with detailed individual monitoring data for external exposure to ionising radiation. Over a mean duration of follow-up of 27 y, the number of observed deaths was 66 632, including 17 957 deaths due to solid cancers, 1791 deaths due to haematological cancers and 27 848 deaths due to cardiovascular diseases. Mean individual cumulative external dose over the period 1945-2005 was 25 mSv. Analyses demonstrated a significant association between red bone marrow dose and the risk of leukaemia (excluding chronic lymphocytic leukaemia) and between colon dose and the risk of solid cancers. INWORKS assembled some of the strongest evidence to strengthen the scientific basis for the protection of adults from low dose, low-dose rate, exposures to ionising radiation.

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