Journal
CHINESE MEDICAL JOURNAL
Volume 128, Issue 11, Pages 1465-1470Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.4103/0366-6999.157653
Keywords
Hemodialysis; Hydrogen Sulfide; Protein Kinase C beta II; Uremic Accelerated Atherosclerosis
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Funding
- National Natural Science Foundation of China [81200543]
- Beijing Natural Science Foundation [7142057]
- Beijing Municipal Health Bureau High-level Medical Professionals Promotion Project [2013-3-016]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development [ZYLX201408]
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Background: Hydrogen sulfide (H2S) plays a protective role in chronic hemodialysis (CHD) patients. In this study, we further investigate the relationship between H-2 S and conventional protein kinase C beta II (cPKC beta II) in CHD patients with uremic accelerated atherosclerosis (UAAS). Methods: A total of 30 healthy people, 30 CHD patients without AS and 30 CHD patients with AS (CHD + AS) were studied. Plasma H2S was measured with a sulfide sensitive electrode, and cPKC beta II membrane translocation was detected by Western blotting. Results: Plasma H2S in CHD + AS group was significantly lower than that in CHD patients. cPKC beta II membrane translocation in CHD + AS group increased significantly compared with CHD group. Plasma H2S concentration was negatively correlated with cPKC beta II membrane translocation in CHD + AS patients. Conclusions: These findings suggest a possible linkage between H2S metabolism and cPKC beta II activation, which may contribute to the development of UAAS in CHD patients.
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