Correlation of Lower Concentrations of Hydrogen Sulfide with Activation of Protein Kinase CβII in Uremic Accelerated Atherosclerosis Patients

Background: Hydrogen sulfide (H2S) plays a protective role in chronic hemodialysis (CHD) patients. In this study, we further investigate the relationship between H-2 S and conventional protein kinase C beta II (cPKC beta II) in CHD patients with uremic accelerated atherosclerosis (UAAS). Methods: A total of 30 healthy people, 30 CHD patients without AS and 30 CHD patients with AS (CHD + AS) were studied. Plasma H2S was measured with a sulfide sensitive electrode, and cPKC beta II membrane translocation was detected by Western blotting. Results: Plasma H2S in CHD + AS group was significantly lower than that in CHD patients. cPKC beta II membrane translocation in CHD + AS group increased significantly compared with CHD group. Plasma H2S concentration was negatively correlated with cPKC beta II membrane translocation in CHD + AS patients. Conclusions: These findings suggest a possible linkage between H2S metabolism and cPKC beta II activation, which may contribute to the development of UAAS in CHD patients.