Journal
PSYCHOPHARMACOLOGY
Volume 233, Issue 23-24, Pages 3881-3890Publisher
SPRINGER
DOI: 10.1007/s00213-016-4420-9
Keywords
Cocaine; Reinstatement; Conditioned place preference; Reward; Self-administration; D1 receptor partial agonist; D3 receptor antagonist
Categories
Ask authors/readers for more resources
Animal research has demonstrated a role of dopamine D1 and D3 receptors in cocaine reward and seeking. Here, we investigated the potential interaction of these two dopamine receptors in cue-induced reinstatement of cocaine seeking, cocaine conditioned place preference (CPP), and cocaine self-administration in rats. The co-administration of a D3 receptor antagonist, NGB 2904 and a D1 partial agonist, SKF 77434, of doses which when administered individually produced no significant effects, prior to reinstatement or CPP tests significantly reduced lever pressing and time spent in the cocaine-paired environment, suggesting synergistic effects of the combined compounds on cocaine seeking. When given to rats self-administering cocaine under a progressive ratio schedule of reinforcement doses of NGB 2904 which were ineffective alone significantly enhanced the break point-reducing effects of SKF 77434. Our results indicate that the combined treatment with a D1 receptor partial agonist and D3 receptor antagonist produces robust decreases in cocaine seeking and reward. This suggests an interaction between dopamine D1 and D3 receptors in cocaine-related behaviors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available