Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 251, Issue -, Pages 53-59Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2016.04.010
Keywords
Gray Matter Volume; Amplitude of Low-Frequency Fluctuation; Functional Connectivity; Group Cognitive Behavioral Therapy
Categories
Funding
- National Natural Science Foundation of China [31271087, 31470981, 31571137, 31500885]
- National Outstanding Young People Plan
- Program for the Top Young Talents by Chongqing
- Fundamental Research Funds for the Central Universities [SWU1509383]
- Natural Science Foundation of Chongqing [cstc2015jcyjA10106]
- China Postdoctoral Science Foundation [2015M572423]
- China Scholarship Council (CSC) [201506990037]
- Innovative Research Project for Postgraduate Student of Chongqing [CYB2015060]
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We used the functional and structural magnetic resonance imaging to explore the neural correlates of response to group cognitive behavioral therapy (CBT) in mild depression. College students with mild depressive symptoms participated in our 4-week group CBT training. The behavioral results showed that depression symptoms decreased after participation in group CBT. After the training, the gray matter volume (GMV) in the right middle frontal gyms (MFG) increased and amplitude of low-frequency fluctuations (ALFF) decreased. In addition, GMV in the left postcentral gyrus decreased after the group CBT. Moreover, the increase of percentage change in the right MFG was positively correlated with the decrease of the Beck Depression Inventory (BDI) score, while less decrease in percentage change in the left postcentral gyms was significantly correlated with greater decrease of BDI score. Finally, after the training, functional connectivity between the right MFG and the insula decreased, while the connectivity between the left postcentral gyms and the parahippocampal gyms increased. These findings suggested that short-term participation in group CBT had an effective impact on mild depression. It contributed to decreasing negative bias (salience detection for negative stimuli). (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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