Journal
PSYCHIATRY RESEARCH
Volume 243, Issue -, Pages 403-406Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2016.06.025
Keywords
Affective disorders; Actigraphy; Pharmacotherapy
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Funding
- National Health and Medical Research Council (NHMRC) Australia [464914]
- Sydney University Research Networks
- Fonds de la recherche en sante du Quebec
- NSW Health, Mental Health and Drug Alcohol Office
- NHMRC [1008117]
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This study investigated the relative contribution of psychiatric symptoms and psychotropic medications on the sleep-wake cycle. Actigraphy and clinical assessments (Brief Psychiatric Rating Scale) were conducted in 146 youths with anxiety, depression or bipolar disorders. Independently of medications, mania symptoms were predictive of lower circadian amplitude and rhythmicity. Independently of diagnosis and symptoms severity: i) antipsychotics were related to longer sleep period and duration, ii) serotonin-norepinephrine reuptalce inhibitors to longer sleep period, and iii) agomelatine to earlier sleep onset. Manic symptoms and different subclasses of medications may have independent influences on the sleep wake cycle of young people with mental disorders. (C) 2016 Published by Elsevier Ireland Ltd.
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