Journal
PSYCHIATRY RESEARCH
Volume 243, Issue -, Pages 185-190Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2016.06.045
Keywords
Paternal age-related schizophrenia (PARS); Early deviance; Social dysfunction; Functional outcome; Interpersonal relationships; Learning disabilities
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Funding
- National Research Foundation Incentive Funding for Rated Researchers [IFRR 103902]
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Consistent associations have been found between advanced paternal age and an increased risk of psychiatric disorders, such as schizophrenia, in their offspring. This increase appears to be linear as paternal age increases. The present study investigates the relationship between early deviant behaviour in the first 10 years of life of patients as well as longer term functional outcome and paternal age in sporadic Afrikaner founder population cases of schizophrenia. This might improve our understanding of Paternal Age-Related Schizophrenia (PARS). Follow-up psychiatric diagnoses were confirmed by the Diagnostic Interview for Genetic Studies (DIGS). An early deviant childhood behaviour semi-structured questionnaire and the Specific Level of Functioning Assessment (SLOF) were completed. From the logistic regression models fitted, a significant negative relationship was found between paternal age at birth and social dysfunction as early deviant behaviour. Additionally, regression analysis revealed a significant negative relationship between paternal age at birth and the SLOF for interpersonal relationships later in life. Early social dysfunction may represent a phenotypic trait for PARS. Further research is required to understand the relationship between early social dysfunction and deficits in interpersonal relationships later in life. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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