One ring to rule them all: Current trends in combating bacterial resistance to the β-lactams

From humble beginnings of a contaminated petri dish, -lactam antibiotics have distinguished themselves among some of the most powerful drugs in human history. The devastating effects of antibiotic resistance have nevertheless led to an arms race with disquieting prospects. The emergence of multidrug resistant bacteria threatens an ever-dwindling antibiotic arsenal, calling for new discovery, rediscovery, and innovation in -lactam research. Here the current state of -lactam antibiotics from a structural perspective was reviewed.