Related references
Note: Only part of the references are listed.Developability Assessment During the Selection of Novel Therapeutic Antibodies
Alexander Jarasch et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Antibody humanization by structure-based computational protein design
Yoonjoo Choi et al.
MABS (2015)
Immunogenicity of therapeutic proteins: Influence of aggregation
Kirsty D. Ratanji et al.
JOURNAL OF IMMUNOTOXICOLOGY (2014)
A general approach to antibody thermostabilization
Audrey D. McConnell et al.
MABS (2014)
Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery
E-Chiang Lee et al.
NATURE BIOTECHNOLOGY (2014)
What's fueling the biotech engine-2012 to 2013
Saurabh Rob Aggarwal
NATURE BIOTECHNOLOGY (2014)
T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation
Vibha Jawa et al.
CLINICAL IMMUNOLOGY (2013)
Structure-Guided Deimmunization of Therapeutic Proteins
Andrew S. Parker et al.
JOURNAL OF COMPUTATIONAL BIOLOGY (2013)
IgBLAST: an immunoglobulin variable domain sequence analysis tool
Jian Ye et al.
NUCLEIC ACIDS RESEARCH (2013)
An integrated approach to extreme thermostabilization and affinity maturation of an antibody
Audrey D. McConnell et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2013)
A divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experiments
Lu He et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2012)
Protein Design Using Continuous Rotamers
Pablo Gainza et al.
PLOS COMPUTATIONAL BIOLOGY (2012)
A novel platform to produce human monoclonal antibodies The next generation of therapeutic human monoclonal antibodies discovery
Marcus Duvall et al.
MABS (2011)
Optimization algorithms for functional deimmunization of therapeutic proteins
Andrew S. Parker et al.
BMC BIOINFORMATICS (2010)
The immunogenicity of humanized and fully human antibodies Residual immunogenicity resides in the CDR regions
Fiona A. Harding et al.
MABS (2010)
Development trends for human monoclonal antibody therapeutics
Aaron L. Nelson et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Computational structure-based redesign of enzyme activity
Cheng-Yu Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Considerations for the development of therapeutic monoclonal antibodies
Patrick G. Swann et al.
CURRENT OPINION IN IMMUNOLOGY (2008)
Analysis and improvements to Kabat and structurally correct numbering of antibody variable domains
K. R. Abhinandan et al.
MOLECULAR IMMUNOLOGY (2008)
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
Frank H. Niesen et al.
NATURE PROTOCOLS (2007)
Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation
Ivica Letunic et al.
BIOINFORMATICS (2007)
A molecular immunology approach to antibody humanization and functional optimization
Greg A. Lazar et al.
MOLECULAR IMMUNOLOGY (2007)
Human antibodies for immunotherapy development generated via a human B cell hybridoma technology
J Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Effects of protein aggregates: An immunologic perspective
Amy S. Rosenberg
AAPS JOURNAL (2006)
From rodent reagents to human therapeutics using antibody guided selection
J Osbourn et al.
METHODS (2005)
Immunogenicity of engineered antibodies
WYK Hwang et al.
METHODS (2005)
Use of human germline genes in a CDR homology-based approach to antibody humanization
WYK Hwang et al.
METHODS (2005)
Antibody humanization by framework shuffling
WF Dall'Acqua et al.
METHODS (2005)
Domain interactions in the Fab fragment:: A comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability
D Röthlisberger et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Protein drug stability: A formulation challenge
S Frokjaer et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
VBASE2, an integrative V gene database
I Retter et al.
NUCLEIC ACIDS RESEARCH (2005)
The clinical pharmacology of therapeutic monoclonal antibodies
LK Roskos et al.
DRUG DEVELOPMENT RESEARCH (2004)
SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity
NR Gonzales et al.
MOLECULAR IMMUNOLOGY (2004)
Structure-immunogenicity relationships of therapeutic proteins
S Hermeling et al.
PHARMACEUTICAL RESEARCH (2004)
Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library
MJ Feldhaus et al.
NATURE BIOTECHNOLOGY (2003)
Immunogenicity of therapeutic proteins: Clinical implications and future prospects
H Schellekens
CLINICAL THERAPEUTICS (2002)
Antibody humanization: a case of the 'Emperor's new clothes'?
M Clark
IMMUNOLOGY TODAY (2000)