Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 110, Issue -, Pages 42-47Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2016.05.007
Keywords
Polyunsaturated fatty acids; Omega-3; Omega-3 index; Mental illness; Depression; Schizophrenia; Cardiovascular disease
Funding
- NHMRC (National Health and Medical Research Council) [320860, 631947]
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Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index) <= 4% is a marker for increased mortality risk from CVD while > 8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk. (C) 2016 Elsevier Ltd. All rights reserved.
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